Waldenström’s macroglobulinemia – a review

Animal Models of Lymphoproliferative Disorders Focusing on Waldenström’s Macroglobulinemia

Iii. Waldenström’s Macroglobulinemia

American Society of Hematology therapy management, and, possibly the outcome. Several investigational agents are under evaluation, and new effective drugs against the neoplastic plasma cells are already available. The outcome of ongoing randomized trials comparing PBSCT and other less toxic chemotherapy regimens will help greatly in optimizing the treatment of this difficult, but now manageable...

A case of Waldenström’s macroglobulinemia treated using clarithromycin and prednisolone

Introduction Macrolides have been considered as potential antineoplastic and immunomodulatory agents. As antineoplastic agents, macrolides show anti-lymphoproliferative effects.[1] Various lymphoid malignancies, such as mucosa-associated lymphoid tissue (MALT) lymphoma,[2] follicular B-cell lymphoma,[3] diffuse large B-cell lymphoma,[4] Waldenström’s macroglobulinemia (WM),[5] multiple myeloma ...

Hypoxia Promotes Dissemination and Colonization in New Bone Marrow Niches in Waldenström's Macroglobulinemia The running title: Role of hypoxia in Waldenström’s Macroglobulinemia Authors:

Waldenström's Macroglobulinemia (WM), a rare and indolent type of non-Hodgkin lymphoma, is characterized by wide spread lymphoplasmacytic B-cells in the bone marrow (BM). Previous studies have shown that hypoxic conditions play a key role in the dissemination of other hematologic malignancies. In this study, the effect of hypoxia was tested on the progression and spread of WM. Interestingly, tu...

Cutaneous amyloidosis as the first presentation of Waldenstrom macroglobulinemia

Background: Waldenstrom macroglobulinemia is a lymphoplasmacytic lymphoma with elevated serum immunoglobulin M and multi-organ involvement. Primary systemic amyloidosis usually develops due to immunoglobulin light chains depositions in different organs due to an underlying gammopathy. Case presentation: Our patient was an 86-year-old man with macroglossia, ecchymotic patches and bullous lesion...